GPAT Syllabus – Download the GPAT 2021 Syllabus PDF Here

GPAT Syllabus: The Graduate Pharmacy Aptitude Test (GPAT) is a National Level Entrance Examination for entry into M. Pharma Programme. GPAT Syllabus is available on the official website of  NTA GPAT. The syllabus helps the students in preparation. The GPAT Syllabus includes Pharmaceutical Chemistry, Pharmaceutics, Pharmacognosy, Pharmacology, and Other Subjects. For more information about GPAT Syllabus, keep reading this article.

GPAT Syllabus

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GPAT Syllabus

The detailed syllabus of GPAT (Graduate Pharmacy Aptitude Test) is given in the below paragraph. Check all the topics carefully, and make a preparation map of the GMAT. Candidates need to prepare each and every topic properly.

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GPAT Physical Chemistry Syllabus

1. Composition & physical states of matter

Intermolecular forces & their impact on the state of the matter. Various physical properties of matter, dipole moment, dielectric constant, Van Der Waal’s equation & critical phenomenon, liquefaction of gases, aerosols.

2. Colligative Properties

The liquid state, vapor pressure, ideal & real solutions. Raoult’s law, the elevation of boiling point, depression of freezing point, osmotic pressure, determination of molecular weight based on colligative properties.

3. Thermodynamics

First, second & third law of thermodynamics. Thermochemical laws, isothermic & adiabatic processes, reversible processes, work of expansion, heat content, enthalpy, heat capacity. Gibb’s & Helmholtz equation & chemical potential.

4. Refractive index

Refractive index, specific refractivity, molar refractivity, refractometers.

5. Solutions

Solubility, factors affecting solubility, solubility curves. Types of solutions, the effect of co-solvency, pH & other factors on solubility. The solubility of gases in liquids, liquids in liquids, & solids in liquids, critical solution temperature, the law of partitioning & its applications. Solute-solvent interactions. Expression of the concentration of pharmaceutical solutions & calculations. Molarity, molality, mole fraction & percentage expressions.

6. Electrochemistry

Properties of electrolyte solutions, electrolysis. Faraday’s law of electrolysis, electron transport, electrical cell, single electrode potential, concentration cells, half-cells & half-cell potential, types of half cells, sign convention, Nernst equation, salt bridge, electromotive series, standard potential, SHE. Measuring the relative voltage of half cells, Calculation of standard potential. Reference & indicator electrodes. Standard oxidation-reduction potential.

7. Ionic equilibrium

Theory of conductivity, equivalent conductance, mobility of ions, specific conductance.

8. Kinetics

Order of reactions, derivation & internal form of rate laws, molarities of reaction, derivation of rate constants.

Physical Pharmacy

1. Matter, properties of matter

States of matter, change in the state of matter, latent heat and vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols- inhalers, relative humidity, liquid complexes, liquid crystals, glasses state, solid crystalline and amorphous polymorphism.

2. Micromeritics and powder rheology

Particle size and distribution, average particle size number and weight distribution, particle number, methods of determining particle size and volume, optical microscopy, sieving, sedimentation, determining surface areas, permeability, adsorption, derived properties of powders, porosity, packing arrangement densities, bulkiness and flow properties.

3. Surface and interfacial phenomenon

Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface and interfacial tension, spreading coefficient, adsorption and liquid interfaces, surface-active agents, HLB classification, solubilization, detergency, absorption at solid interfaces, solid-gas and solid-liquid interfaces, complex films, electrical properties of interfaces.

4. Viscosity and rheology

Newtonian systems, the law of flow, kinematics viscosity, the effect of temperature, non- Newtonian systems, pseudoplastic, dilatant, plastic, thixotropy in formulations, determination of viscosity and thixotropy by capillary, falling ball, rotational viscometer, application of theology in pharmacy

5. Dispersion systems

  • a. Colloidal dispersions: Definition, Types, properties of colloids, protective colloids, application of colloids in pharmacy.
  • b. Suspensions and emulsions: Interfacial properties of suspended particles settling in suspension, the theory of sedimentation, the effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, the significance of electrical properties in dispersions, controlled flocculation, flocculation in structured vehicles, rheological considerations, emulsions: types, theories, physical stability.

6. Complexation

Classification of complexes, methods of preparations and analysis, applications.

7. Buffer

Buffer equations and buffer capacity in general. Buffers in pharmaceutical systems, preparations, and stability, buffered isotonic solutions. Measurements of tonicity calculations and methods of adjusting isotonicity.

8. Solubility

a. Miscibility-influence of foreign substances
b. Concepts of dissolution and diffusion.

Organic Chemistry

1. General principles
2. Different classes of compounds
3. Protection & deprotection of groups
4. Aromaticity & chemistry of aromatic compounds
5. Different aromatic classes of compounds
6. Polycyclic aromatic hydrocarbons
7. Carbonyl Chemistry
8. Heterocyclic Chemistry
9. Bridged rings
10. Kinetic & thermodynamic control
11. Stereochemistry

Pharmaceutical Chemistry

Pharmaceutical Inorganic Chemistry
  • 1. Pharmaceutical Impurities
  • 2. Monographs
  • 3. Isotopes
  • 4. Dentifrices, desensitizing agents, & anticaries agents
Medicinal Chemistry
  • 5. Therapeutic classes of drugs
  • 6. Various classes of therapeutic agents
  • 7. Different classes of therapeutic drugs
  • 8. Different classes of therapeutic drugs

GPAT Pharmaceutics Syllabus

1. Pharmacy Profession & Introduction to Pharmaceuticals

2. Introduction to a dosage form

3. Sources of drug information

4. Allopathic dosage form

5. Crude extract

6. Allergenic extract

7. Biological products

8. Pharmaceutical Plant, location, layout

9. Dosage Form Necessities and Additives

10. Powders

11. Capsules

12. Tablets

13. Parenterals

14. Suspensions

15. Emulsions

16. Suppositories

17. Semisolids

18. Liquids

19. Pharmaceutical Aerosols

20. Ophthalmic preparations

21. Preformulations

22. Stability of formulated products

23. Prolonged Action Pharmaceuticals

24. Novel Drug delivery system

25. GMP and Validation

26. Packaging Materials

27. Cosmetics

28. Pilot plant scale-up techniques


1. General Pharmacology

2. Neurohumoral transmission in the autonomic and central nervous system

3. Pharmacology of peripheral nervous system

4. Pharmacology of central nervous System

5. Pharmacology of cardiovascular system

6. Drugs acting on the urinary system

7. Drugs acting on the Respiratory system

8. Pharmacology of the Endocrine system

9. Chemotherapy

10. Autacoids and their Antagonists

11. Pharmacology of drug acting on the gastrointestinal tract

12. Chronopharmacology

13. Immunopharmacology

14. Vitamins & Minerals

15. Principles of toxicology


1. Introductory Pharmacognosy

2. Classification of crude drugs

3. Factors influencing the quality of crude drugs

4. Techniques in microscopy

5. Introduction to phytoconstituents

6. Principles of plant classification

7. Pharmaceutical aids

8. Animal products

9. Plant products

10. Toxic drugs

11. Enzymes

12. Natural pesticides and insecticides

13. Adulteration and evaluation of crude drugs

14. Quantitative microscopy

15. Biogenetic pathways

16. Carbohydrates & lipids

17. Tannins

18. Volatile oils

19. Resinous drugs

20. Glycosides

21. Alkaloids

22. Extraction and Isolation Techniques

23. Phytopharmaceuticals

24. Quality control and standardization of herbal drugs

25. Herbal formulations

26. Worldwide trade of crude drugs and volatile oils

27. Herbal cosmetics

28. Traditional herbal drugs

29. Plants based industries and research institutes in India.

30. Patents

31. Ayurvedic system of medicine

32. Homeopathic system of medicine


Sibaram Sannigrahi

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